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Synthesis 2025; 57(15): 2289-2306
DOI: 10.1055/a-2516-2906
DOI: 10.1055/a-2516-2906
short review
Recent Progress in Base-Metal-Catalyzed Dearomative Reaction of N-Heteroarenes
We are grateful to National Natural Science Foundation of China (22001068), Natural Science Foundation of Hunan Province (2022JJ10034) for financial support.
Abstract
Three-dimensional nitrogen-containing heterocyclic compounds widely exist in many natural products and drugs. The dearomatization of N-heteroarenes and their derivatives have been recognized as one of the most important and powerful strategies for the rapid and efficient synthesis of various three-dimensional nitrogen-containing heterocyclic compounds. In this short review, the recent and representative advances in base-metal-catalyzed dearomatization of N-heteroarenes are summarized and discussed.
1 Introduction
2 Dearomatization of Indoles
2.1 Copper Catalysis
2.2 Nickel Catalysis
2.3 Cobalt Catalysis
2.4 Other Catalysts
3 Dearomatization of Pyridines, Quinolines, Isoquinolines, and Pyrazine
3.1 Copper Catalysis
3.2 Nickel Catalysis
3.3 Cobalt Catalysis
3.4 Other Catalysts
4 Summary and Outlook
Key words
base metal catalysis - N-heterocycles - dearomatization - copper catalysis - nickel catalysis - cobalt catalysisPublication History
Received: 03 December 2024
Accepted after revision: 14 January 2025
Accepted Manuscript online:
14 January 2025
Article published online:
27 February 2025
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