Abstract
Three-dimensional nitrogen-containing heterocyclic compounds widely exist in many
natural products and drugs. The dearomatization of N-heteroarenes and their derivatives have been recognized as one of the most important
and powerful strategies for the rapid and efficient synthesis of various three-dimensional
nitrogen-containing heterocyclic compounds. In this short review, the recent and representative
advances in base-metal-catalyzed dearomatization of N-heteroarenes are summarized and discussed.
1 Introduction
2 Dearomatization of Indoles
2.1 Copper Catalysis
2.2 Nickel Catalysis
2.3 Cobalt Catalysis
2.4 Other Catalysts
3 Dearomatization of Pyridines, Quinolines, Isoquinolines, and Pyrazine
3.1 Copper Catalysis
3.2 Nickel Catalysis
3.3 Cobalt Catalysis
3.4 Other Catalysts
4 Summary and Outlook
Key words
base metal catalysis -
N-heterocycles - dearomatization - copper catalysis - nickel catalysis - cobalt catalysis
